1. Desmoplastic melanoma

    The risk of spread and ultimate death from invasive melanoma depends on several factors, but the main one is the measured thickness of the melanoma at the time it was surgically removed. There are conflicting reports about prognostic indicators and outcomes for desmoplastic melanoma, due to its rarity, differences in pathological interpretation, and differing study designs/methodology. The results of three studies are described below.

    5-year overall survival rates were better for 280 patients with localised desmoplastic melanoma (90%, median Breslow thickness 2.5 mm) compared to 7767 patients with non-desmoplastic melanoma (82%, median Breslow thickness 1.6 mm).
    A study of 1129 desmoplastic melanoma patients in the United States (1992–2007) reported a 5-year specific survival rate of 85% and 10-year survival of 80%. Older age, anatomic site of the head and neck and tumour thickness > 2 mm, ulceration, lymph node involvement and non-receipt of surgery were associated with ...

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