1. Articles in category: Physical

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    1. Improved Diagnostic and Prognostic Strategies For Desmoplastic Melanoma - SkinCancer.org

      Improved Diagnostic and Prognostic Strategies For Desmoplastic Melanoma - SkinCancer.org

      The recurrence rate is as high as 20 percent in neurotropic DM cases vs. only 6.8 percent in non-neurotropic DM cases.1 It has also been shown that DMs excised with margins <1 cm have a higher rate of local recurrence than those excised with margins >2 cm.1,17

      However, there are cases where wide margins and deep excisions are not feasible, for example with DMs that are deeply infiltrating or located in cosmetically, structurally, or functionally sensitive areas such as the periorbital or periocular regions of the face.25,28 In these circumstances, adjuvant radiation therapy may improve local control of the disease

      Conclusion

      Although DM can be a diagnostic challenge for clinicians and pathologists, certain clues may improve detection and aid in diagnosis of these tumors. For instance, diagnosis of DM should be considered when evaluating nonspecific, scar-like lesions displaying irregular vessels under dermoscopy

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    2. Desmoplastic Melanoma: A Review

      Desmoplastic Melanoma: A Review

      CONCLUSIONS AND RECOMMENDATIONS
      DM can be a diagnostic challenge for clinicians and pathologists alike, because of its non-specific and often banal appearance. Multiple pitfalls exist in achieving the correct diagnosis including the initial clinical diagnosis as a benign entity, partial biopsies that are insufficient to render a pathologic diagnosis, and interpretation error under the microscope. We offer some final recommendations which can aid in the diagnostic and management decisions

      Any clinically suspect LMM should be palpated due to the association of DM with LMM. If a dermal firm nodule is noted, one needs to consider the possibility of a DM component.
      An excisional biopsy, whenever feasible, is the preferred biopsy method for suspect lesions.
      The pathologic distinction between pure and mixed DM should be documented since this distinction is likely to help inform diagnostic and management decisions.
      WLE with clear margins (when feasible, a 2 cm margin) is important for ...

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    3. Julia Louis-Dreyfus: 'Laughter was the best medicine during cancer battle'

      Julia Louis-Dreyfus: 'Laughter was the best medicine during cancer battle'

      Julia Louis-Dreyfus reflected on how "laughter was the best medicine" during her cancer battle as she received the Mark Twain Prize for American Humor on Sunday (21Oct18).

      The Veep actress was honoured with the coveted prize at the Kennedy Center in Washington, D.C. on Sunday night, and when she received the award, the star reflected on her breast cancer battle. Revealing she was diagnosed with the disease 12 hours after she won her sixth consecutive Emmy Award for Outstanding Lead Actress in a Comedy Series for Veep in September, 2017, Julia labelled it a "hilarious turn of events".

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